Histological study and immunohistochemical expression of StAR protein in the suprarenal cortex of adult male rats associated with sleep disturbance

The present study was designed to investigate the effects of sleep disturbance on histological features and evaluates expression StAR protein in cortex adrenal gland adult male rats. suprarenal glands are endocrine organs that directly affected by deprivation. Sleep is a stress factor affecting steroidogenesis since it regulated hypothalamic-pituitary axis (HPA). Its hormones cholesterol-derived, they use Acut regulating plays an essential critical role mediating cholesterol transfer inner mitochondrial membrane side chain cleavage enzyme system. This research aims (sleep disruption deprivation) changes Comparing experimental groups controls, alterations such as cellular hypertrophy vascular dilatation cortical zones were found mainly Zona fasculata Zf. Immunohistochemistry used identify significant level StAR, which showed higher value interruption group compared control deprivation at p-value ≤ 0.001. indicates has more impact than deprivation, increases gland. Keywords: gland; disturbance; protein; steroidogenesis; circadian rhythms.